Thrombelastography and coagulation parameters in septic patients and their clinical significance

This study aimed to study the clinical significance of the thrombelastography (TEG) and coagulation parameters in septic patients. 92 septic patients were divided into three groups: sepsis group, sever sepsis group, and septic shock group. At the same time, they were divided into survival group and death group according to their outcomes. Results showed that the difference in days of hospitalization, hemoglobin, CRP and PCT among the three groups was statistically significant (P<0.05). The difference in PT, APTT, TT, FIB, INR and D-Dimer among the three groups was not statistically significant (P>0.05), but D-Dimer in septic shock group was higher than in the other groups. The results of TEG showed that the difference interactiontime (R), K time, α-angle, maximal amplitude (MA), platelet function, and clot index (CI) among the three groups were statistically significant (P<0.05). K, α-angle, MA, platelet function and CI in septic shock group were significantly lower than in sepsis group and sever sepsis group (P<0.05). R in sever sepsis group was significantly shorter than in the other groups. And α-angle, MA, platelet function and CI in sever sepsis group were significantly higher than in sepsis group (P<0.05). The difference in R, K, α-angle, MA, platelet function and CIof TEG between survival group and death group was statistically significant (P<0.05). Taken together, TEG contributes to the diagnosis of coagulability and prognosis in sepsis patients.